Is CBD Addictive? Can You Get Addicted to Hemp Oil?


The endogenous opioid system is closely involved in the regulation of addictive behaviors. Opioid peptides do not directly affect dopaminergic neurons function in the VTA but inhibit gamma-aminobutyric acid (GABAergic) interneurons that innervate VTA dopaminergic neurons in the mesolimbic system (Johnson and North, 1992). Some drugs of abuse (e.g., alcohol, cannabis) stimulate the release of endogenous opioids leading to a MOR-mediated increase of DA release in the NAcc (Tanda and Di Chiara, 1998). The present review shows the current state of the art about the potential interest of CBD as a new pharmacological avenue for SUD. According to the findings from preclinical and clinical studies, CBD alone or in combination with commonly employed treatment strategies in drug addiction may configure a potential therapeutic option for improving the dishabituation process of addicted patients.

What are proven health benefits?

This discussion also thoroughly reviews CBD’s mechanism of action, adverse event profile, and ongoing research trials involving this drug. Additionally, understanding CBD’s pharmacology helps healthcare professionals to tailor treatment plans to individual patient needs. Enhancing patient care and optimizing outcomes in epilepsy, neuropathic pain, and anxiety disorders requires emphasis on the critical role of the interprofessional healthcare team in overseeing CBD therapy. In recent years, the major role of hippocampal neurogenesis in the addictive process has become increasingly established (Mandyam and Koob, 2012; Chambers, 2013; Deroche-Gamonet et al., 2019). A number of reports suggests that psychoactive substances with addictive potential modify neurogenesis in the adult HIPP (Castilla-Ortega et al., 2016).

  • While there is still more research to be done into long-term effects, it is important that we consider CBD separately from the side effects of marijuana and its reputation.
  • With so much misinformation and junk-science on the internet, it is important to get solid facts from doctors and scientists you can trust before deciding if medical marijuana could help you.
  • Main findings from clinical and animal studies aimed to evaluate the therapeutic potential of CBD for the treatment of tobacco use disorder.

What is the difference between CBD and CBN?

Cannabidiol (CBD), the second most abundant component of cannabis, is thought to modulate various neuronal circuits involved in drug addiction. The goal of this systematic review is to summarize the available preclinical and clinical data on the impact of CBD on addictive behaviors. MEDLINE and PubMed were searched for English and French language articles published before 2015. In all, 14 studies were found, 9 of which were conducted on animals and the remaining 5 on humans.

What’s the difference between hemp seed oil and CBD hemp oil?

It has been proposed that CBD could act as a partial agonist of D2 receptors (Seeman, 2016) and normalize D3 receptor gene expression in several brain regions (PFC, HIPP, and NAcc) (Stark et al., 2020). Tobacco use is the cause of over 8 million deaths per year globally, resulting one of the biggest public health threats worldwide (World Health Organization (WHO), 2020). Nicotine is the main addictive substance responsible for cigarette smoking and withdrawal is cannabidiol addictive symptoms occurring upon smoking cessation. Nowadays, nicotine replacement therapy together with varenicline, a nicotinic receptor partial agonist, is the most effective smoking cessation drug. However, a significant proportion or smokers still fail to maintain long-term abstinence. Here we reviewed the scarce but recent results pointing out CBD as a candidate to be considered for modulating nicotine-induced reinforcing and withdrawal symptoms.

is cannabidiol addictive

According to the previous evidence, it seems that CBD could play a crucial role in the management of CUD. The clinical studies that are underway as well as future investigations will be decisive to determine the therapeutic application of CBD to treat cannabis addiction. They found that CBD inhibited the decrease of the ICSS threshold by morphine and thus its reward-facilitating effect, without influencing motor function. Moreover, the 5-HT1A receptor antagonist reversed CBD’s impact on the reward-facilitating effect of morphine. Farm Bill was passed, federal law removed hemp-derived products from the Drug Enforcement Agency’s list of Schedule 1 substances.

  • Ren et al studied the postmortem brain of rats and found that CBD normalized the heroin-induced changes in CB1 receptor mRNA expression and AMPA GluR1 in the nucleus accumbens, even after 2 weeks of treatment.
  • Morgan et al studied the impact of CBD on nicotine addiction by conducting a randomized, double-blind, placebo-controlled study on 24 smokers who wished to stop smoking.33 Two groups received either a CBD inhaler (400 μg/inhalation) or a placebo inhaler.
  • This shows the results of a company’s testing for THC, CBD and various contaminants.
  • Most drug screening tests look for a compound created by the body when it metabolizes THC.
  • However, CBD products containing more than 0.3% THC still fall under the legal definition of marijuana, making them illegal at the federal level.

Furthermore, the administration of CBD blocked the increase of dopamine transporter (DAT) and TH gene expressions in the VTA of mice exposed to the cocaine withdrawal (Gasparyan et al., 2020). Stimulant use disorder is defined by the DSM-5 as the continued use of amphetamine-type substances, cocaine, or other stimulants leading to clinically significant impairment or distress, from mild to severe (APA, 2013). The global prevalence of stimulant use has increased over the past decade with a worrying rise in the use of amphetamine-type stimulants and cocaine (United Nations Office on Drugs and Crime, 2019). Amphetamine-type stimulants include substances with a similar chemical structure, such as amphetamine and methamphetamine, and other structurally different but with similar effects, such as methylphenidate. Amphetamine-type stimulants as well as cocaine are highly addictive substances. One of the main concerns is the lack of specific pharmacological tools for the treatment of amphetamine-type or cocaine use disorder.

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Cannabidiol (CBD): What we know and what we don’t – Harvard Health

Cannabidiol (CBD): What we know and what we don’t.

Posted: Thu, 04 Apr 2024 07:00:00 GMT [source]

While CBD is an essential component of medical marijuana, it is derived directly from the hemp plant, a cousin of marijuana, or manufactured in a laboratory. One of hundreds of components in marijuana, CBD does not cause a high by itself. While CBD does not appear to be addictive and may have some benefits, one large-scale review concluded that there was not enough evidence to support the use of CBD as a treatment for mental health conditions. Evidence suggests that people can develop a tolerance to THC and may experience withdrawal symptoms. Physical dependence on THC is more likely among people who use high-THC cannabis strains. Because marijuana can be addictive, particularly when it is used heavily and at high doses, you might wonder if CBD addiction is also possible.

How cannabis can affect your health

is cannabidiol addictive

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  • Of the preclinical studies, five dealt with opioid, one with psychostimulant, one with opioid and psychostimulant, and two with cannabis addiction.
  • We recommend consulting your doctor if you take any pharmaceutical medications and are afraid CBD may interfere with them.
  • “Here we have [cannabinoid] drugs that work on multiple receptors and have multiple effects.
  • In a recent document, the FDA highlighted the potential beneficial effects of cannabis derivatives.
  • This high rate of recurrence is largely due to the ineffectiveness of the available drugs or the lack of specific treatments (e.g., cannabis, cocaine, or amphetamine-type use disorders).